The aim of the study is to evaluate dimensions of stress, coping resources and psychological dissease in infertile couples. To 101 couples (101 man and 101 woman) undergoing furtilate traitement with in-vitro fertilization was administered a test batery consisting of Italian versions of Furtilite Problem Inventory (FPI, Newton, Sherrard, Glavac, 1999; Zurlo, Ambrosino, 2011), Edinburg Depression Inventory (EDS, Cox et. al., 1987; Benvenuti et. al. 1999), State-Trait Inventory, Form Y (STAI-Y, Spielberger, 1976; Pedrabissi, Santinello, 1989), Dyadic Adjustment Scale (Spanier, 1976; Gentili et. al., 2002) and Coping Orientations to Problems Experienced - Nuova Versione Italiana (COPE-NVI; Carver et. al., 1989; Sica et. al., 2008) Infertility-related stress, anxiety and depressive experinces, coping strategies and dyadic adjustment were analysed in relation to gender, age, educational level, duration and type of infertility diagnosis. Corelations between dyadic adjustment and coping strategies used by infetiles couples and percieved stress related to infertility were analyzed. The ınfluance of dyadic adjustments and coping strategies used and of percieved infertilety-related stress on the levels of perceived anxiety and depression were evaluated.