This paper proposes some considerations concerning the diagnostic process and the psychological intervention with infertile patients. The effects of infertility on psychological life are interpreted referring to a psychoanalytic approach to the filiation bonds which considers the intersection of the psychic (narcissistic and imaginary) dimension, with both the biomedical dimesion and the institutional dimension of symbolization of filiation. In this perspective, a multi-methodological and integrated procedure of psychological assessment of infertile patients is described.